List of Knock-in Rat Models to Study Alzheimer’s Disease and Dementia Generated by Luciano D’Adamio’s lab at RUADRC
| Disease Type | Mutation(s) | Citation/Reference |
| PATHOGENIC FAMILIAL | ITM2b Danish mutation | Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Møller M, Braendgaard H, Plant G, Ghiso J, Frangione B A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4920-5. PubMed: 10781099 |
| PATHOGENIC FAMILIAL | APP KM670/671NL (Swedish) | https://www.alzforum.org/mutations/app-km670671nl-swedish |
| PATHOGENIC FAMILIAL | PSEN1 L424F | https://www.alzforum.org/mutations/psen1-l424f |
| PATHOGENIC SPORADIC | TREM2 R47H | https://www.alzforum.org/mutations/trem2-r47h |
| PATHOGENIC SPORADIC | ABCA7 7bp deletion | https://www.alzforum.org/alzpedia/abca7 |
| SPORADIC (2 protective, 4 pathogenic) | APOE2/3/4 | http://www.alzgene.org/geneoverview.asp?geneid=83 |
| PROTECTIVE | APP A673T (Icelandic) | https://www.alzforum.org/mutations/app-a673t-icelandic |